Combined treatment with cisplatin and radiation therapy for mouse Cl 300 neuroblastoma.

Abstract

The efficacy of the combined treatment of cisplatin and radiation therapy for mouse C1 300 neuroblastoma was studied. Intraperitoneal cisplatin injections and/or radiation were given from 7 to 21 days after inoculation of the tumor cells into the thigh region of A/Jax mice. The combination of 15 Gy radiation and 6 mg/kg cisplatin had an additive effect on both tumour growth delay and survival rate, while that of 30 Gy radiation and 6 mg/kg cisplatin had a synergistic effect. The efficacy of the combined therapy was dependent on the dose of radiation but not on the dose of cisplatin. The normal skin of the mouse was damaged in the similar pattern with both treatments. Thus, cisplatin has a potent radiosensitising effect in the treatment of mouse neuroblastoma.

• Authors: K Ishimaru, A Nakagawara, Y Zaizen, K Ikeda
• Journal: Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood (Z Kinderchir) Vol. 40 Issue 1 Pg. 36-9 (Feb 1985) ISSN: 0174-3082 [Print] Germany
• PMID: 4039094 (Publication Type: Journal Article)

Chemical References

• Cisplatin

Topics

• Animals
• Cell Line
• Cisplatin (therapeutic use)
• Combined Modality Therapy
• Dose-Response Relationship, Drug
• Male
• Mice
• Mice, Inbred A
• Neoplasm Transplantation
• Neuroblastoma (radiotherapy)
• Radiotherapy Dosage