Abstract |
We have shown first, that apoB mediates the binding of small VLDL Sf 20-60 and IDL, as well as LDL, to the LDL receptor. Second, apoE of an appropriate, accessible conformation is required for the binding of large VLDL to the LDL receptor; HTG-VLDL Sf greater than 60 but not normal VLDL Sf greater than 60 have this apoE population. Third, the same population of apoE that mediates binding of HTG-VLDL Sf greater than 60 to the LDL receptor modulates its binding to the beta-VLDL receptor, but it is not required for the latter interaction. Fourth, a domain of processed apoB or apoB-48 in association with a domain of the inaccessible apoE is required for binding to and uptake by the beta-VLDL receptor. Fifth, our observations suggest that the abnormal catabolism of VLDL that occurs in hypertriglyceridemia may be explained by the abnormal uptake of HTG-VLDL by either the LDL or the beta-VLDL receptor pathway. Finally, we suggest that plasma proteases may route apoB/E-containing lipoproteins to macrophages for disposal, and this results in foam cell formation.
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Authors | S H Gianturco, A M Gotto Jr, W A Bradley |
Journal | Advances in experimental medicine and biology
(Adv Exp Med Biol)
Vol. 183
Pg. 47-71
( 1985)
ISSN: 0065-2598 [Print] United States |
PMID | 4036704
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins B
- Apolipoproteins E
- Lipoproteins
- Lipoproteins, IDL
- Lipoproteins, LDL
- Lipoproteins, VLDL
- Receptors, LDL
- Triglycerides
- VLDL receptor
- Thrombin
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Topics |
- Apolipoproteins B
(metabolism)
- Apolipoproteins E
(metabolism)
- Arteriosclerosis
(metabolism)
- Cells, Cultured
- Fibroblasts
(metabolism)
- Humans
- Hyperlipoproteinemia Type IV
(metabolism)
- Lipoproteins
(metabolism)
- Lipoproteins, IDL
- Lipoproteins, LDL
(metabolism)
- Lipoproteins, VLDL
(metabolism)
- Macrophages
(metabolism)
- Receptors, LDL
(metabolism)
- Structure-Activity Relationship
- Thrombin
(metabolism)
- Triglycerides
(metabolism)
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