[Modifying effect of thyroid gland functional disorders on realization of transplacental carcinogenesis induced by N-nitrosomethylurea in rats].

Abstract

The paper discusses the influence of deranged function of the thyroid (in postnatal period) on the transplacental carcinogenic effect of N-nitrosomethylurea (NMU) in albino noninbred rats. It was found that exogenous thyroxin-induced hyperthyroidism and thyroid function suppression either by long-term treatment with a thyreostatic agent--methylthiouracil (MTU) or thyroidectomy are followed by a lower frequency of, chiefly, nervous system tumors which are typical of NMU-induced transplacental carcinogenesis in rats. Moreover, transplacental treatment with NMU potentiated the carcinogenic effect of MTU on the thyroid. The latter manifested itself in a higher frequency of malignancies of the thyroid in animals exposed to a combined treatment with NMU (transplacentally) and MTU (postnatally) as compared with those given MTU only (postnatally).

• Authors: I G Popovich, V A Aleksandrov, G A Blinova, N P Napalkov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 31 Issue 8 Pg. 79-85 ( 1985) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Modifitsiruiushchee vliianie narusheniia funktsii shchitovidnoĭ zhelezy na realizatsiiu transplatsentarnogo kantserogeneza, indutsirovannogo N-nitrozometilmochevinoĭ u krys.
• PMID: 4036068 (Publication Type: English Abstract, Journal Article)

Chemical References

• Methylnitrosourea
• Thyroxine
• Methylthiouracil

Topics

• Animals
• Brain Neoplasms (chemically induced)
• Female
• Maternal-Fetal Exchange
• Methylnitrosourea
• Methylthiouracil (toxicity)
• Neoplasms, Experimental (chemically induced)
• Pregnancy
• Rats
• Thyroid Gland (physiology)
• Thyroid Neoplasms (chemically induced)
• Thyroidectomy
• Thyroxine (toxicity)