Teratological assessment of five oxidative hair dyes in the rat.

Abstract

The oxidative dyes, 4,4'-diaminodiphenylene sulfate, N'-(2-hydroxyethyl)-4-nitro-O-phenylenediamine, N,N-dimethyl-p-phenylenediamine, 2,3-dihydroxynaphthalene, and resorcinol, were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation Days 6 through 15 at doses ranging from 12.5 to 500 mg/kg. No overt signs of toxicity were observed during the treatment period. A significant reduction in mean maternal weight gain was noted during the treatment period at the high dose for 4,4'-diaminodiphenylene sulfate, N'-(2-hydroxyethyl)-4-nitro-O-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for N,N-dimethyl-p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant reduction in maternal weight gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of vitamin A, the positive control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses.

• Authors: J C DiNardo, J C Picciano, R W Schnetzinger, W E Morris, B A Wolf
• Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 78 Issue 1 Pg. 163-6 (Mar 30 1985) ISSN: 0041-008X [Print] United States
• PMID: 4035668 (Publication Type: Journal Article)

Chemical References

• Hair Dyes
• Hair Preparations
• Phenylenediamines
• Resorcinols
• Teratogens
• dimethyl-4-phenylenediamine
• resorcinol

Topics

• Animals
• Dose-Response Relationship, Drug
• Female
• Hair Dyes (toxicity)
• Hair Preparations (toxicity)
• Oxidation-Reduction
• Phenylenediamines (toxicity)
• Pregnancy
• Rats
• Rats, Inbred Strains
• Resorcinols (toxicity)
• Teratogens