Abstract |
Hairless mice with subcutaneously transplanted Lewis Lung carcinomas were used to study the effects of treatments with hematoporphyrin derivative (HPD) administered by intratumoral injection, followed by exposure to red light. A tumor cure rate of 70-90% was obtained following a single treatment. The therapeutic response increased with increasing HPD doses and light fluences. At a certain dose a plateau seemed to be reached, where further dose increase only gave a limited gain in treatment response. A narrow range seems to exist between beginning therapeutic response and frank necrotic destruction. The number of mice that died after treatment increased with increase in tumor size, and there was a correspondence between the time of death and the severity of the phototoxic reactions. The best therapeutic response was obtained when the irradiation was performed 1/2-1 h after injection, and with tumors less than 6-8 mm in diameter.
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Authors | D Moseng, G Volden, K Midelfart, G Kavli, T Christensen, J Moan |
Journal | Photo-dermatology
(Photodermatol)
Vol. 2
Issue 2
Pg. 107-10
(Apr 1985)
ISSN: 0108-9684 [Print] Denmark |
PMID | 4034416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Hematoporphyrins
(administration & dosage, adverse effects, therapeutic use)
- Mice
- Mice, Hairless
- Neoplasm Transplantation
- Photochemotherapy
- Skin Neoplasms
(drug therapy)
- Time Factors
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