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[Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole].

Abstract
The results of combined treatment of 98 laryngeal cancer patients followed up for 1.5-3 years were analysed. Of them 68 received a preoperative radiotherapy course combined with the electron acceptor compound metronidazole. The drug was given in the form of a sugar syrup suspension at a dose of 100-150 mg/kg bw 2.5-3 hours before each of the 4 fractions of irradiation, at 5 Gy twice a week reaching a summary focal dose of 20 Gy. Thirty patients received radiation therapy without metronidazole. Altogether 4 preoperative radiotherapy methods were used. An analysis of the results showed a significant improvement of the cure rates for laryngeal cancer patients using metronidazole, particularly for those with advanced stages. A better healing of postoperative wounds was noted. The author proved the appropriateness of preoperative irradiation by mean fractions up to a summary focal dose of 20 Gy combined with metronidazole and subsequent (on the last or next day of irradiation) radical operation.
AuthorsV G Andreev
JournalMeditsinskaia radiologiia (Med Radiol (Mosk)) Vol. 30 Issue 8 Pg. 6-10 (Aug 1985) ISSN: 0025-8334 [Print] Russia (Federation)
Vernacular TitleKombinirovannoe (luchevoe i khirurgicheskoe) lechenie bol'nykh rakom gortani s ispol'zovaniem metronidazola.
PMID4033393 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Metronidazole
Topics
  • Adult
  • Aged
  • Carcinoma, Squamous Cell (mortality, pathology, therapy)
  • Combined Modality Therapy
  • Humans
  • Laryngeal Neoplasms (mortality, pathology, therapy)
  • Laryngectomy
  • Lymphatic Metastasis
  • Metronidazole (therapeutic use)
  • Middle Aged
  • Neoplasm Staging
  • Papilloma (mortality, pathology, therapy)
  • Preoperative Care
  • Radiotherapy Dosage

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