Abstract |
The results of combined treatment of 98 laryngeal cancer patients followed up for 1.5-3 years were analysed. Of them 68 received a preoperative radiotherapy course combined with the electron acceptor compound metronidazole. The drug was given in the form of a sugar syrup suspension at a dose of 100-150 mg/kg bw 2.5-3 hours before each of the 4 fractions of irradiation, at 5 Gy twice a week reaching a summary focal dose of 20 Gy. Thirty patients received radiation therapy without metronidazole. Altogether 4 preoperative radiotherapy methods were used. An analysis of the results showed a significant improvement of the cure rates for laryngeal cancer patients using metronidazole, particularly for those with advanced stages. A better healing of postoperative wounds was noted. The author proved the appropriateness of preoperative irradiation by mean fractions up to a summary focal dose of 20 Gy combined with metronidazole and subsequent (on the last or next day of irradiation) radical operation.
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Authors | V G Andreev |
Journal | Meditsinskaia radiologiia
(Med Radiol (Mosk))
Vol. 30
Issue 8
Pg. 6-10
(Aug 1985)
ISSN: 0025-8334 [Print] Russia (Federation) |
Vernacular Title | Kombinirovannoe (luchevoe i khirurgicheskoe) lechenie bol'nykh rakom gortani s ispol'zovaniem metronidazola. |
PMID | 4033393
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(mortality, pathology, therapy)
- Combined Modality Therapy
- Humans
- Laryngeal Neoplasms
(mortality, pathology, therapy)
- Laryngectomy
- Lymphatic Metastasis
- Metronidazole
(therapeutic use)
- Middle Aged
- Neoplasm Staging
- Papilloma
(mortality, pathology, therapy)
- Preoperative Care
- Radiotherapy Dosage
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