[Laboratory and clinical studies on cefpimizole in the field of gynecology].

Abstract

Cefpimizole (AC-1370), a new cephalosporin antibiotic, was evaluated for its distribution in uterine tissue, penetration into retroperitoneal exudate and therapeutical effects on some infections in gynecology. The following results were obtained; The levels of AC-1370 in the cubital vein were similar to those in the uterine artery and this remained in the course of examinations after an 1 g intravenous injection. Seven patients with gynecological infections received AC-1370 by intravenous injection. The overall efficacy rate was 85.7%. No adverse reaction was observed in any of the cases treated with AC-1370, nor was there any marked changes in the laboratory findings.

• Authors: H Nakamura, J Nakamura, Y Iwata, S Hayashi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 4 Pg. 966-71 (Apr 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4032733 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• cefpimizole

Topics

• Adult
• Bacterial Infections (drug therapy)
• Cephalosporins (administration & dosage, metabolism, therapeutic use)
• Drug Evaluation
• Exudates and Transudates (metabolism)
• Female
• Genital Diseases, Female (drug therapy)
• Genitalia, Female (metabolism)
• Humans
• Injections, Intravenous
• Middle Aged
• Retroperitoneal Space