[Evaluation of the clinical effect and tissue distribution of cefpimizole in the field of gynecology].

Abstract

Cefpimizole (AC-1370) was administered to 5 cases with uterine myoma before hysterectomy, and tissue distribution was determined. AC-1370 was also administered to 5 cases with gynecological infections. The following results were obtained. One gram of AC-1370 was administered from 43 to 299 minutes before hysterectomy, tissue distribution of AC-1370, such as ovary, oviduct, myometrium, cervix uteri, and portio vaginalis was showed the highest level (30.0 approximately 49.5 micrograms/g) at 43 minutes after administration, and these were 39.0 approximately 64.4% of the concentration in uterine arterial blood. Tissue concentration of AC-1370 was then gradually decreased following with the decreasing of the concentration in uterine arterial blood. AC-1370 was administered to 3 cases with pyometra, 1 case with Bartholin abscess, 1 case with adnexitis. The clinical efficacy was good in all 5 cases. Bacteriological study revealed that A. faecalis and E. coli were eradicated, but B. fragilis was persisted. No side effect was observed in all cases.

• Authors: M Murata, E Ogawa, M Maki
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 4 Pg. 915-20 (Apr 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4032728 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• cefpimizole

Topics

• Adult
• Bacterial Infections (drug therapy)
• Cephalosporins (administration & dosage, metabolism, therapeutic use)
• Drug Evaluation
• Female
• Genital Diseases, Female (drug therapy)
• Genitalia, Female (metabolism)
• Humans
• Infusions, Parenteral
• Middle Aged
• Pregnancy
• Tissue Distribution