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Testicular changes in rats after administration of organotin complex.

Abstract
Intratesticular administration of di-n-butyltin (o-hydroxyacetophenone S-methyldithiocarbazate) has been shown to induce marked degenerative changes in the testes of adult rats. The possible mechanism of its action is discussed. In particular, an atrophy of seminiferous tubules with complete arrest of spermatogenesis has been noted.
AuthorsA Saxena, J K Koacher, J P Tandon
JournalJournal of toxicology and environmental health (J Toxicol Environ Health) Vol. 15 Issue 3-4 Pg. 503-7 ( 1985) ISSN: 0098-4108 [Print] United States
PMID4032496 (Publication Type: Journal Article)
Chemical References
  • Organotin Compounds
Topics
  • Animals
  • Male
  • Organotin Compounds (toxicity)
  • Rats
  • Spermatogenesis (drug effects)
  • Testis (drug effects, pathology)

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