Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration.

Abstract

Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil (A-OT) against MH134 solid tumors in mice was studied following subcutaneous and oral administration and compared with that of 5-fluorouracil (5-FU) administered subcutaneously at doses of 0.2, 0.4 and 0.6 mmol/kg/d. Oral administration of A-OT demonstrated a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of A-OT. Anti-tumor activity of oral administration of A-OT at a dose of 0.2 mmol/kg/d was comparable to that of subcutaneous administration of 5-FU at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of A-OT at any dose were smaller than those by subcutaneous administration of 5-FU (0.2 mmol/kg/d).

• Authors: N Yata, R Yamajo, T Okada
• Journal: Journal of pharmacobio-dynamics (J Pharmacobiodyn) Vol. 8 Issue 4 Pg. 264-9 (Apr 1985) ISSN: 0386-846X [Print] Japan
• PMID: 4032217 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• 1-acetyl-3,2-toluyl-5-fluorouracil
• Fluorouracil

Topics

• Administration, Oral
• Animals
• Antineoplastic Agents (pharmacology)
• Female
• Fluorouracil (analogs & derivatives, pharmacology)
• Injections, Subcutaneous
• Liver Neoplasms, Experimental (drug therapy, pathology)
• Mice
• Mice, Inbred C3H
• Organ Size (drug effects)
• Spleen (drug effects)
• Thymus Gland (drug effects)