Thirty-two patients with
common variable immunodeficiency (CVID) and two patients with
IgA and
IgG subclass deficiency received a total of 1,040 intravenous (i.v.) infusions during 60 patient years with 7,575 g of a new
immunoglobulin (Ig) preparation. The content of
prekallikrein activators and the anti-complementary activity in the tested Ig preparation was low and, in comparison to seven other commercial i.v. Igs, so was the proportion of
IgG polymers and fragments. The
IgA content was always less than or equal to 0.02 g/l, often less than 0.004 g/l, and it was possible to continuously give the Ig prophylactically to four patients with
anti-IgA antibodies, i.e. three with CVID and one with combined IgA-IgG2 deficiency. Adverse reactions were only noted in 4.7% of the 1,040 infusions and in 12 out of the 34 patients. None of the reactions were of the anaphylactic type, but two patients had moderate reactions and one had
anuria, probably not caused by the Ig. A simultaneous
infection seemed to increase the risk of phlogistic reactions, as five out of six patients who reacted with temperature rise and
chills had a simultaneous
upper respiratory tract infection. A substudy of various dosage schedules was performed with 11 patients receiving 203 infusions over 10.8 patient years. On 25 mg/kg/week of Ig given i.v. every five weeks, a mean increase in the preinfusion serum
IgG level of 0.3 g/l was observed, as compared to earlier i.m. prophylaxis with the same dose. Only 1/4 of the patients on 25 mg/kg/week every five or three weeks reached a preinfusion
IgG level greater than or equal to 3 g/l.(ABSTRACT TRUNCATED AT 250 WORDS)