Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule.

Abstract

After vaginal insertion of a 300-mg ovule of tioconazole in 10 patients with vaginal candidiasis, the mean concentration in plasma was 21.2 ng/ml (range, 10.6 to 35.8 ng/ml) at 8 h and was not measurable at 24 h in 9 of 10 patients. The mean vaginal concentration at 24 h was 21.4 mg/liter (range, 2.4 to 50 mg/liter) and remained detectable in 7 of 9 and 2 of 9 patients after 48 and 72 h, respectively.

• Authors: E T Houang, A G Lawrence
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 27 Issue 6 Pg. 964-5 (Jun 1985) ISSN: 0066-4804 [Print] United States
• PMID: 4026270 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Imidazoles
• Suppositories
• tioconazole

Topics

• Absorption
• Antifungal Agents (administration & dosage, metabolism)
• Body Fluids (metabolism)
• Female
• Humans
• Imidazoles (administration & dosage, metabolism)
• Suppositories
• Time Factors
• Vagina (metabolism)