Thiazide diuretics and bone mineral content in postmenopausal women.

Abstract

This retrospective study of 54 postmenopausal women taking thiazide diuretics found that bone mineral measurements and bone fracture prevalence did not differ significantly from those of matched control subjects. Matching on the variables of type of menopause (surgical/nonsurgical), years postmenopausal, duration of estrogen therapy (if any), daily intake of dietary and supplemental calcium and vitamin D, and Quetelet index was done without knowledge of the bone mineral measurements. Bone mass was recorded as the bone mineral content and bone density of the distal and midshaft radius. Only fractures associated with osteoporosis (hip, rib, vertebrae, and wrist) were recorded. This study suggests that thiazide diuretics do not provide protection against osteoporosis.

• Authors: P Adland-Davenport, M W McKenzie, M Notelovitz, L C McKenzie, J F Pendergast
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 152 Issue 6 Pt 1 Pg. 630-4 (Jul 15 1985) ISSN: 0002-9378 [Print] United States
• PMID: 4025422 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Benzothiadiazines
• Calcium, Dietary
• Diuretics
• Estrogens
• Minerals
• Sodium Chloride Symporter Inhibitors
• Vitamin D

Topics

• Aged
• Benzothiadiazines
• Bone and Bones (analysis)
• Calcium, Dietary (therapeutic use)
• Diuretics
• Estrogens (therapeutic use)
• Female
• Fractures, Spontaneous (etiology)
• Humans
• Menopause
• Middle Aged
• Minerals (analysis)
• Osteoporosis (complications, prevention & control)
• Retrospective Studies
• Sodium Chloride Symporter Inhibitors (therapeutic use)
• Time Factors
• Vitamin D (therapeutic use)