Akinesia and mutism following a methylphenidate challenge test.

Abstract

A case of akinesia and mutism is described in a menopausal, depressed woman with onset following a mood challenge with 40 mg of methylphenidate taken orally over a 3-hour period. Various diagnoses are considered with preference given on clinical grounds to conversion disorder precipitated by drug-induced dysphoria. It is suggested that increased susceptibility to dysphoria may have been related to prior clomipramine administration and hypoestrogenism.

• Authors: J Wiener, S Kennedy
• Journal: Journal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 5 Issue 4 Pg. 231-3 (Aug 1985) ISSN: 0271-0749 [Print] United States
• PMID: 4019811 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Methylphenidate

Topics

• Adult
• Akinetic Mutism (chemically induced, diagnosis)
• Catatonia (diagnosis)
• Conversion Disorder (diagnosis)
• Depressive Disorder (drug therapy)
• Diagnosis, Differential
• Epilepsy (diagnosis)
• Female
• Humans
• Methylphenidate (adverse effects)