HLA and lymphocyte histamine sensitivity in mastocytosis.

Abstract

HLA-ABC and DR typing was performed on 50 patients with mastocytosis. Lymphocyte stimulation with concanavalin A has earlier been performed in 22 of these patients. No phenotypic aberrations were detected in the patient group. 8 patients had the HLA-B12 phenotype. Lymphocytes from the HLA-B12 phenotype stimulated with a lymphocyte mitogen have earlier been shown to react with decreased inhibitory effect to histamine. 2 patients in this study had the HLA-B12 phenotype and systemic mastocytosis with high histamine turnover, but these patients reacted with a low mitogen response of the lymphocytes.

• Authors: J H Olafsson, G Roupe, L Rydberg
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 77 Issue 4 Pg. 430-2 ( 1985) ISSN: 0020-5915 [Print] Switzerland
• PMID: 4018885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• HLA-B Antigens
• HLA-B12 antigen
• Concanavalin A
• Histamine

Topics

• Adult
• Aged
• Concanavalin A (pharmacology)
• Female
• HLA Antigens (immunology)
• HLA-B Antigens
• Histamine (metabolism, pharmacology)
• Humans
• In Vitro Techniques
• Lymphocyte Activation (drug effects)
• Lymphocytes (drug effects, immunology)
• Male
• Middle Aged
• Urticaria Pigmentosa (immunology, metabolism)