Gastrin has no promoting effect on chemically induced colonic tumors in Wistar rats.

Abstract

The effects of prolonged administration of tetragastrin from the beginning of intrarectal instillation of 1 ml of 0.25% N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and after MNNG-treatment on the incidence and histology of colonic tumors were compared in inbred Wistar rats. In week 35 prolonged administration of testragastrin in depot form from the beginning of MNNG-treatment resulted in a significant reduction in the incidence of colonic tumors and a significant increase in the incidence of mucinous adenocarcinoma, unlike the well-differentiated adenocarcinoma produced in controls without gastrin. In contrast, prolonged administration of tetragastrin after MNNG-treatment had little or no influence on the incidence, size or histology of colonic tumors. Thus tetragastrin had no promoting effect on colonic tumors.

• Authors: M Tatsuta, H Yamamura, H Iishi, S Noguchi, M Ichii, H Taniguchi
• Journal: European journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 21 Issue 6 Pg. 741-4 (Jun 1985) ISSN: 0277-5379 [Print] England
• PMID: 4018115 (Publication Type: Journal Article)

Chemical References

• Gastrins
• Tetragastrin
• Methylnitronitrosoguanidine

Topics

• Adenocarcinoma (chemically induced)
• Animals
• Cocarcinogenesis
• Colonic Neoplasms (chemically induced, pathology)
• Drug Administration Schedule
• Gastrins (toxicity)
• Male
• Methylnitronitrosoguanidine
• Neoplasm Metastasis
• Rats
• Rats, Inbred Strains
• Tetragastrin (administration & dosage, toxicity)