Gastrin has no promoting effect on chemically induced colonic tumors in Wistar rats.

The effects of prolonged administration of tetragastrin from the beginning of intrarectal instillation of 1 ml of 0.25% N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and after MNNG-treatment on the incidence and histology of colonic tumors were compared in inbred Wistar rats. In week 35 prolonged administration of testragastrin in depot form from the beginning of MNNG-treatment resulted in a significant reduction in the incidence of colonic tumors and a significant increase in the incidence of mucinous adenocarcinoma, unlike the well-differentiated adenocarcinoma produced in controls without gastrin. In contrast, prolonged administration of tetragastrin after MNNG-treatment had little or no influence on the incidence, size or histology of colonic tumors. Thus tetragastrin had no promoting effect on colonic tumors.
AuthorsM Tatsuta, H Yamamura, H Iishi, S Noguchi, M Ichii, H Taniguchi
JournalEuropean journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 21 Issue 6 Pg. 741-4 (Jun 1985) ISSN: 0277-5379 [Print] ENGLAND
PMID4018115 (Publication Type: Journal Article)
Chemical References
  • Gastrins
  • Tetragastrin
  • Methylnitronitrosoguanidine
  • Adenocarcinoma (chemically induced)
  • Animals
  • Cocarcinogenesis
  • Colonic Neoplasms (chemically induced, pathology)
  • Drug Administration Schedule
  • Gastrins (toxicity)
  • Male
  • Methylnitronitrosoguanidine
  • Neoplasm Metastasis
  • Rats
  • Rats, Inbred Strains
  • Tetragastrin (administration & dosage, toxicity)

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