[Changes in the chemotherapy sensitivity of leukemia L1210 cells during the development of diazan resistance].

Abstract

L 1210 leukemia strain resistant to diazan (L 1210/D1) was studied for its drug sensitivity in comparison with the parent strain. The resistant strain exhibited significantly higher sensitivity to nine drugs: dopan, sarcolysine, apirazidin, cyclophosphane, 6-mercaptopurine, thiophosphamide, rubomycin, vinblastine and vincristine. L 1210/D1 gained cross resistance to four drugs: 1-(2-chloroethyl)-3-(2, 6-dioxy-3-piperidyl)-1-nitrosourea, methotrexate, 5-fluorouracil and ftorafur. The resistant strain sensitivity remained unchanged (in comparison with the parent strain) to seven drugs: degranol, prospidin, nitrosomethylurea, chlorozotocin, deazauridine, bleomycin and L-asparaginase (crasnitine).

• Authors: S A Goncharova, V N Shevtsova, N S Demidova, N P Konovalova
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 7 Issue 3 Pg. 56-9 ( 1985) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Izmenenie chuvstvitel'nosti k khimioterapii kletok leĭkoza L1210 pri razvitii ustoĭchivosti k diazanu.
• PMID: 4017934 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Diazonium Compounds
• diazan

Topics

• Animals
• Antineoplastic Agents (antagonists & inhibitors)
• Diazonium Compounds (antagonists & inhibitors)
• Drug Evaluation, Preclinical
• Drug Resistance
• Leukemia L1210 (drug therapy)
• Mice