2,3-Dihydroxybenzoic acid. Effect on mortality rate in a septic rat model.
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| Abstract |
Neutrophil-derived oxygen-free radicals may play a role in organ dysfunction associated with generalized sepsis. A rat model was used to test the effects of two free radical scavengers, dimethyl sulfoxide (DMSO) and 2,3-dihydroxybenzoic acid (2,3-DHB), on mortality from intra-abdominal sepsis produced by cecal ligation and perforation. Being an iron-chelating agent, 2,3-DHB may have an additional bacteriostatic effect. Therapeutic regimens included no treatment; gentamicin sulfate (2 mg given intraperitoneally [IP] every eight hours); DMSO (2 g/24 hr given IP every eight hours in divided doses); 2,3-DHB (35 mg/kg given IP every eight hours); and combinations of gentamicin with each free radical scavenger. No statistically significant improvement in survival was obtained by therapeutic intervention with gentamicin alone, DMSO alone, 2,3-DHB alone, or gentamicin in combination with DMSO. When used in combination with gentamicin, 2,3-DHB yielded a statistically significant improvement in survival when compared with gentamicin alone or with no treatment. These results show that 2,3-DHB when used in combination with gentamicin has a beneficial effect on mortality following intra-abdominal sepsis in this model.
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| Authors | R A Pearce, R J Finley, R A Mustard Jr, J H Duff |
| Journal | Archives of surgery (Chicago, Ill. : 1960) (Arch Surg) Vol. 120 Issue 8 Pg. 937-40 (Aug 1985) ISSN: 0004-0010 [Print] United States |
| PMID | 4015386 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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