Abstract |
Salmon calcitonin (sCT, 2 and 20 U/kg), porcine calcitonin (pCT, 20 and 40 U/kg) and human calcitonin (hCT, 20 and 40 U/kg) were injected subcutaneously to rats trained to eat their food during two hours each day. Food intake and serum Ca++ concentrations were determined at the end of 2h-feeding period. A long lasting anorectic effect was observed for 20 U/kg of sCT with a parallelism between hypocalcaemia and anorexia in the first 8 hours after treatment; on the contrary, rats continued to eat less than controls in the following hours when their serum Ca++ concentrations had risen to normal or even higher levels. As regards pCT and hCT, it was shown that these peptides reduced significantly meal size only for 1-2 hours when serum Ca++ levels were at their lowest levels for these peptides.
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Authors | R Gaggi, E Beltrandi, R Dall'Olio, S Ferri |
Journal | Pharmacological research communications
(Pharmacol Res Commun)
Vol. 17
Issue 3
Pg. 209-15
(Mar 1985)
ISSN: 0031-6989 [Print] United States |
PMID | 4011645
(Publication Type: Journal Article)
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Chemical References |
- Appetite Depressants
- salmon calcitonin
- Calcitonin
- Calcium
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Topics |
- Animals
- Appetite Depressants
- Calcitonin
(pharmacology)
- Calcium
(blood)
- Depression, Chemical
- Eating
(drug effects)
- Male
- Rats
- Rats, Inbred Strains
- Swine
- Time Factors
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