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Serum trihexyphenidyl levels in the treatment of torsion dystonia.

Abstract
Using a radioreceptor technique, we assayed serum trihexyphenidyl levels in patients with dystonia being treated chronically with high dosage. We found a significant correlation between total daily dose and the daily lowest (trough) serum levels. There was no relationship between serum levels and therapeutic response or toxicity. Toxicity was more closely related to patient age than to serum level. Although levels may be useful to monitor patient compliance, they cannot be used to judge adequacy of therapy.
AuthorsR E Burke, S Fahn
JournalNeurology (Neurology) Vol. 35 Issue 7 Pg. 1066-9 (Jul 1985) ISSN: 0028-3878 [Print] United States
PMID4010950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Trihexyphenidyl
Topics
  • Animals
  • Dystonia Musculorum Deformans (blood, drug therapy)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Trihexyphenidyl (blood)

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