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Nitrite: a co-carcinogen?

Abstract
The concurrent administration of N-nitroso-N-methylbenzylamine (NMBA) (10 mg/l drinking water) and sodium nitrite (5 g or 1 g/kg basic diet) induces enhanced progression of esophageal tumors. Pathologic changes of the respiratory system, which do not occur with administration of NMBA alone, are also observed. These findings call for re-evaluation of the toxicological significance of nitrite.
AuthorsF Schweinsberg, V Bürkle
JournalJournal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 109 Issue 3 Pg. 200-2 ( 1985) ISSN: 0171-5216 [Print] Germany
PMID4008514 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Nitrites
  • nitrosobenzylmethylamine
  • Sodium Nitrite
  • Dimethylnitrosamine
Topics
  • Animals
  • Cocarcinogenesis
  • Dimethylnitrosamine (analogs & derivatives)
  • Drug Synergism
  • Esophageal Neoplasms (chemically induced)
  • Female
  • Neoplasms, Experimental (chemically induced)
  • Nitrites (toxicity)
  • Rats
  • Respiratory System (drug effects, pathology)
  • Sodium Nitrite (toxicity)

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