[Hepatitis and pancreatitis due to indalpine].

Abstract

The authors report two cases of hepatitis and a case of pancreatitis associated with indalpine. In one case of hepatitis, onset was acute and the clinical presentation was suggestive of cholecystitis; in the other case, hepatitis was discovered by biological tests. In the two cases, hepatitis was mainly cytolytic. Outcome was favorable upon interruption of drug administration. Onset of pancreatitis was inconspicuous, with progressively increasing pain. The pancreatic lesions were diffuse and massive. After interruption of administration, outcome was eventually favorable. Elevated amylasemia was also noted in the two cases of hepatitis. It is suggested that transaminase and amylase activities should be monitored during indalpine therapy.

• Authors: Y Calmus, M Biour, F Bodin, G Cheymol, F Darnis
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 9 Issue 3 Pg. 266-8 (Mar 1985) ISSN: 0399-8320 [Print] France
• Vernacular Title: Hépatites et pancréatite à l'indalpine.
• PMID: 4007381 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antidepressive Agents
• Piperidines
• indalpine

Topics

• Aged
• Antidepressive Agents (adverse effects)
• Chemical and Drug Induced Liver Injury (etiology)
• Female
• Humans
• Middle Aged
• Pancreatitis (chemically induced)
• Piperidines (adverse effects)