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A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county, China.

Abstract
Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.
AuthorsS J Cheng, Y Z Jiang, M H Li, H Z Lo
JournalCarcinogenesis (Carcinogenesis) Vol. 6 Issue 6 Pg. 903-5 (Jun 1985) ISSN: 0143-3334 [Print] England
PMID4006077 (Publication Type: Journal Article)
Chemical References
  • Mutagens
  • Polyenes
  • fusarin C
Topics
  • Animals
  • China
  • Chromosome Aberrations
  • Cricetinae
  • Cricetulus
  • Esophageal Neoplasms (etiology)
  • Fusarium (metabolism)
  • In Vitro Techniques
  • Mutagenicity Tests
  • Mutagens
  • Polyenes (isolation & purification)
  • Sister Chromatid Exchange
  • Zea mays (microbiology)

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