Abstract |
Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.
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Authors | S J Cheng, Y Z Jiang, M H Li, H Z Lo |
Journal | Carcinogenesis
(Carcinogenesis)
Vol. 6
Issue 6
Pg. 903-5
(Jun 1985)
ISSN: 0143-3334 [Print] England |
PMID | 4006077
(Publication Type: Journal Article)
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Chemical References |
- Mutagens
- Polyenes
- fusarin C
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Topics |
- Animals
- China
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Esophageal Neoplasms
(etiology)
- Fusarium
(metabolism)
- In Vitro Techniques
- Mutagenicity Tests
- Mutagens
- Polyenes
(isolation & purification)
- Sister Chromatid Exchange
- Zea mays
(microbiology)
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