6-Nitrochrysene is a potent tumorigen in newborn mice.

Abstract

A newborn mouse (BLU:Ha) lung adenoma bioassay demonstrated that 6-nitrochrysene was a highly potent tumorigen. It induced 100% incidence of lung tumors and a 150-fold increase in their number (20.84 tumors/mouse) at the lowest dose level tested (total dose: 38.5 micrograms/mouse). 70% of the 6-nitrochrysene treated mice had malignant lung tumors (adenocarcinomas). Lymphomas and nodular hyperplasia of the liver were also observed in treated, but not control, animals. The tumorigenicity of 6-nitrochrysene relative to other polynuclear aromatic hydrocarbons and their mononitro-derivatives has been discussed.

• Authors: W F Busby Jr, R C Garner, F L Chow, C N Martin, E K Stevens, P M Newberne, G N Wogan
• Journal: Carcinogenesis (Carcinogenesis) Vol. 6 Issue 5 Pg. 801-3 (May 1985) ISSN: 0143-3334 [Print] England
• PMID: 4006066 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Chrysenes
• Phenanthrenes
• 6-nitrochrysene

Topics

• Adenoma (chemically induced)
• Animals
• Animals, Newborn
• Carcinogens
• Chrysenes (toxicity)
• Dose-Response Relationship, Drug
• Female
• Liver (pathology)
• Lung Neoplasms (chemically induced)
• Male
• Mice
• Phenanthrenes (toxicity)