Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.

Abstract	The pharmacokinetics of acebutolol and its major metabolite, diacetolol, following a single 400 mg oral dose, were investigated in patients with liver disease. No significant differences were found in any of the parameters measured.
Authors	R Zaman, D B Jack, M R Wilkins, M J Kendall
Journal	Biopharmaceutics & drug disposition (Biopharm Drug Dispos) 1985 Apr-Jun Vol. 6 Issue 2 Pg. 131-7 ISSN: 0142-2782 [Print] England
PMID	4005393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	diacetolol Acebutolol
Topics	Acebutolol (analogs & derivatives, blood, metabolism) Aged Chromatography, High Pressure Liquid Female Half-Life Humans Kinetics Liver Diseases (metabolism) Liver Function Tests Male Middle Aged

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