Single-dose pharmacokinetic and pharmacodynamic comparison of polymer-matrix (Slow Trasicor) and Oros dosage forms of oxprenolol in healthy volunteers.

Abstract

Oxprenolol was administered in single doses by mouth to healthy volunteers either in a polymer-matrix slow-release formulation (Slow Trasicor) or in osmotic drug-delivery systems (oxprenolol Oros). Plasma oxprenolol concentrations and heart rates after exercise were measured. Plasma concentrations of the drug were maximal at 3 h but negligible at 24 h after administration of Slow Trasicor. Following ingestion of the Oros systems measurable concentrations were maintained throughout 24 h. Significant reduction of exercise-induced tachycardia persisted for 24 h after administration of oxprenolol Oros. With Slow Trasicor heart rate responses had returned to baseline values by this time. The osmotic drug-delivery systems appear to sustain significant beta-adrenoceptor blockade for 24 h after a single oral dose.

• Authors: P N Bennett, J Bennett, I Bradbrook, J Francis, V A John, H Rogers, P Turner, S J Warrington
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 19 Suppl 2 Pg. 171S-175S ( 1985) ISSN: 0306-5251 [Print] England
• PMID: 4005119 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Delayed-Action Preparations
• Oxprenolol

Topics

• Adult
• Delayed-Action Preparations
• Female
• Heart Rate (drug effects)
• Humans
• Kinetics
• Male
• Oxprenolol (administration & dosage, metabolism, pharmacology)
• Physical Exertion