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Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.

Abstract
Twenty-nine healthy volunteers participated in an experiment lasting for 8 weeks: Phase I (2 weeks)--pre-treatment control period; Phase II (4 weeks)--medication with either ciclazindol hydrochloride (50 mg twice daily), or desipramine hydrochloride (50 mg twice daily) or lactose placebo (twice daily) administered in a single-blind fashion; Phase II (2 weeks)--recovery. Experimental sessions took place twice weekly for the photographic assessment of resting pupil diameter, and for the assessment of one of the following pupillary responses: mydriatic response to methoxamine, mydriatic response to tyramine, miotic response to pilocarpine. Resting pupil diameter increased during medication with either ciclazindol or desipramine. Methoxamine-evoked mydriasis and tyramine-evoked mydriasis were antagonized by both ciclazindol and desipramine. Pilocarpine-evoked miosis was potentiated by both ciclazindol and desipramine. The steady-state plasma levels (mean +/- s.e. mean) of the antidepressants were: ciclazindol: 5.90 +/- 0.74 microM; desipramine: 0.60 +/- 0.17 microM. The antagonism of methoxamine-evoked mydriasis is likely to reflect the blockade of postsynaptic alpha 1-adrenoceptors in the iris by the antidepressants, whereas the antagonism of tyramine-evoked mydriasis may reflect both the blockade of uptake of tyramine into presynaptic adrenergic terminals and the blockade of postsynaptic alpha-adrenoceptors. There is no immediate explanation for the potentiation of pilocarpine-evoked miosis by the two antidepressants.
AuthorsF A Kerr, E Szabadi
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 19 Issue 5 Pg. 639-47 (May 1985) ISSN: 0306-5251 [Print] England
PMID4005103 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Indoles
  • Pilocarpine
  • Methoxamine
  • Desipramine
  • Tyramine
  • ciclazindol
Topics
  • Adolescent
  • Adult
  • Antidepressive Agents, Tricyclic (blood, pharmacology)
  • Desipramine (blood, pharmacology)
  • Female
  • Humans
  • Indoles (blood, pharmacology)
  • Male
  • Methoxamine (pharmacology)
  • Pilocarpine (pharmacology)
  • Pupil (drug effects)
  • Tyramine (pharmacology)

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