Plasma concentrations of fibrinopeptide A and fibrinopeptide B beta 15-42 in glomerulonephritis and the nephrotic syndrome.

Abstract

Plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. An increase in plasma FPA and B beta 15-42 levels was noted in these patients; this increase was marked in the nephrotic patients. There was a positive correlation in these patients between plasma FPA and B beta 15-42 levels. The B beta 15-42/FPA ratio was significantly higher in nonnephrotic patients compared with controls. Intravascular coagulation with subsequent fibrinolysis to regulate fibrin formation may occur in patients. A positive correlation was found between plasma B beta 15-42 level and serum urea nitrogen or serum creatinine concentration, suggesting that plasma B beta 15-42 level is influenced not only by plasmin action, but also by renal dysfunction.

• Authors: S Tomura, Y Oono, R Kuriyama, J Takeuchi
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 145 Issue 6 Pg. 1033-5 (Jun 1985) ISSN: 0003-9926 [Print] United States
• PMID: 4004427 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Fibrinogen Degradation Products
• Peptide Fragments
• Serum Albumin
• fibrinogen Bbeta (15-42)
• Fibrinopeptide A
• Fibrinopeptide B
• Fibrinogen
• Cholesterol
• Creatinine

Topics

• Adolescent
• Adult
• Blood Coagulation
• Blood Urea Nitrogen
• Cholesterol (blood)
• Creatinine (blood)
• Fibrin Fibrinogen Degradation Products
• Fibrinogen (analysis)
• Fibrinolysis
• Fibrinopeptide A (analysis)
• Fibrinopeptide B (analysis)
• Glomerulonephritis (blood, metabolism)
• Humans
• Middle Aged
• Nephrotic Syndrome (blood, metabolism)
• Peptide Fragments (analysis)
• Radioimmunoassay
• Serum Albumin (analysis)