Clinical study of muzolimine in acute renal failure, pharmacodynamics and pharmacokinetics.

Abstract

UNLABELLED:

The aim of this study was to test the efficiency of muzolimine in patients with acute renal failure (ARF).

METHODS:

6 patients, all males, 46 to 78 years old (mean 67.3 +/- 12.5) suffering from acute renal failure as a complication of a surgical procedure (4 cases) or a medical disease (2 cases) were selected. Creatinine clearance rates were below 20 ml/min for all subjects except one (mean: 14.4 ml/min range 4-34), blood urea levels from 21 to 65 mmol/l (mean = 36.4); mean urinary output, during the 24 hours preceding the study (D-1) was 100.4 +/- 57 ml/h (range 36-208) without any diuretic treatment. No patient was on dialysis. On the treatment day a single oral dose of muzolimine (240 mg) was administered in the morning. During the treatment day (D0) and the post treatment day (D + 1), pharmacodynamics and pharmacokinetics were evaluated. Mean urinary output increased from 1.67 +/- 0.95 ml/min, at D-1 to 3.24 +/- 2 ml/min at D0 (NS), with great differences between patients. The main effect was noted between 0 and 6 hours after the ingestion of muzolimine. The mean electrolyte output increased from D0 to D1 for Na+ (0.1 mmol/min +/- 0.08----0.25 +/- 0.1-NS), K+ (0.05 mmol/min +/- 0.02----0.08 +/- 0.07-NS), Cl- (0.07 +/- 0.07 mmol/min----0.30 +/- 0.12 p less than 0.05) and Ca++ (1.89 +/- 1.89 meq/24 h----4.1 +/- 2 NS), with large individual variations. Mean urea output increased slightly in only 3 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: P Bouletreau, J Meunier, J C Kérihuel, W Ritter
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 74 Suppl 2 Pg. 96-9 ( 1985) ISSN: 0300-5860 [Print] Germany
• PMID: 4002812 (Publication Type: Journal Article)

Chemical References

• Electrolytes
• Pyrazoles
• Muzolimine

Topics

• Acute Kidney Injury (blood, drug therapy, physiopathology)
• Aged
• Blood Chemical Analysis
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Electrolytes (blood)
• Female
• Heart Rate (drug effects)
• Humans
• Kinetics
• Male
• Middle Aged
• Muzolimine (adverse effects, blood, therapeutic use)
• Pyrazoles (therapeutic use)