Research in the Division of Medicinal Chemistry.

Abstract

Within the Center for Bio-Pharmaceutical Sciences research on medicinal chemistry is centered around two themes: receptor recognition and photochemistry of drugs. Extremely little is known about the conformation of receptor recognition sites. The approach that should lead to a more detailed knowledge is outlined. Similarly the interaction between enzymes and their inhibitors will be studied. The photochemistry of drugs can be useful (phototherapy) or harmful (phototoxicity). The phototoxicity of benzodiazepines was found to be attributable to the formation of oxaziridines on the N-oxide groups.

• Authors: W Soudijn
• Journal: Pharmaceutisch weekblad. Scientific edition (Pharm Weekbl Sci) Vol. 7 Issue 2 Pg. 71-4 (Apr 26 1985) ISSN: 0167-6555 [Print] Netherlands
• PMID: 4000902 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors

Topics

• Academies and Institutes
• Chemistry, Pharmaceutical
• Drug Stability
• Enzyme Inhibitors (pharmacology)
• Models, Molecular
• Netherlands
• Photochemistry
• Research