Mutagenic evaluation of nitroparaffins in the Salmonella typhimurium/mammalian-microsome test and the micronucleus test.

Abstract

Three nitroparaffins (nitroethane, 1-nitropropane, and 2-nitropropane) were studied in the Salmonella typhimurium/mammalian microsome (Ames) test, with and without microsomal activation systems. Nitroethane and 2-nitropropane also were studied in an in vivo mutagenic (micronucleus) test. These studies were undertaken because these solvents are widely used in the chemical and pharmaceutical industries and 2-nitropropane was reported to cause liver cancer in rats exposed by the inhalation route. Neither nitroethane nor 1-nitropropane was active in the Ames test with Salmonella tester-strains TA1537, TA92, TA98, or TA100. However, 2-nitropropane produced a significant increase in revertants in all of these tester strains, particularly strain TA100, where 3 microliter/plate doubled the number of revertants in the presence of microsomal enzymes. Negative results were obtained with both nitroethane and 2-nitropropane in micronucleus tests. These studies have shown that 2-nitropropane has the potential for causing point mutations in a microbial test system. However, this compound probably will not cause a chromosome mutation of the clastogenic type.

• Authors: M Hite, H Skeggs
• Journal: Environmental mutagenesis (Environ Mutagen) Vol. 1 Issue 4 Pg. 383-9 ( 1979) ISSN: 0192-2521 [Print] United States
• PMID: 399919 (Publication Type: Journal Article)

Chemical References

• Alkanes
• Mutagens
• Nitroparaffins

Topics

• Alkanes (pharmacology)
• Cell Nucleus (ultrastructure)
• Mutagenicity Tests
• Mutagens
• Nitroparaffins (pharmacology)
• Salmonella typhimurium (genetics)