[Effect of antihypoxic agents on the blood supply and function of the intact and ischemic myocardium].

Abstract

It was established in experiments on cats anesthesized with nembutal that the antihypoxic drugs sodium hydroxybutyrate, piracetam and glio-6 increased blood outflow from the coronary heart sinus. This was accompanied by a rise in the content of oxyhemoglobin in coronary venous blood. Sodium hydroxybutyrate was shown to exhibit the highest and most prolonged effect. On the contrary, the effect of glio-6 did not last long. All the antihypoxic drugs enhanced myocardial contractility without changing or slightly reducing the pulse rate. In experimental acute coronary circulation failure (temporary occlusion of the coronary artery with the recording of the epicardial electrogram), sodium hydroxybutyrate and, to a lesser degree, piracetam were discovered to improve the function of the focus of myocardial ischemia. A single administration of glio-6 did not affect the focus of acute myocardial ischemia.

• Authors: G G Chichkanov, I B Tsorin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1985 Mar-Apr Vol. 48 Issue 2 Pg. 49-54 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: O vliianii nekotorykh antigipoksantov na krovosnabzhenie i funktsional'noe sostoianie intaktnogo i ishemizirovannogo miokarda.
• PMID: 3996570 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Glyoxylates
• Sodium Oxybate
• glyoxylic acid
• Piracetam

Topics

• Animals
• Cats
• Coronary Circulation (drug effects)
• Coronary Disease (drug therapy, physiopathology)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Electrocardiography
• Glyoxylates (therapeutic use)
• Heart (drug effects, physiology)
• Hemodynamics (drug effects)
• Hypoxia (prevention & control)
• Piracetam (therapeutic use)
• Sodium Oxybate (therapeutic use)
• Time Factors