Effects of zinc acexamate on gastric mucosal resistance factors.

Abstract

The effects of zinc acexamate on gastric defensive systems were evaluated in the rat. Gastric ulcers induced by oral administration of three necrotic agents (0.6 N HCl, 25% NaCl, 100% ethanol) were markedly reduced by different pretreatments with zinc acexamate. This cytoprotective effect was not modified by previous treatment with indomethacin (30 mg/kg orally). Zinc acexamate pretreatment also prevents the disruption of the gastric mucosal barrier induced by aspirin (40 mM) and increases mucus production in the gastric glands and tracheal walls. These observations suggest that the antiulcer effects described for zinc salts could be the result, at least partly, of an action increasing gastric mucosal defensive systems.

• Authors: J V Esplugues, O Bulbena, G Escolar, E Martí-Bonmatí, J Esplugues
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 109 Issue 2 Pg. 145-51 (Feb 26 1985) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3996471 (Publication Type: Journal Article)

Chemical References

• Aminocaproates
• 6-acetylaminocaproic acid
• Zinc
• Aminocaproic Acid

Topics

• Aminocaproates (pharmacology)
• Aminocaproic Acid (pharmacology)
• Animals
• Female
• Gastric Mucosa (drug effects, pathology)
• Mucus (physiology)
• Necrosis
• Rats
• Rats, Inbred Strains
• Stomach Ulcer (drug therapy)
• Trachea (drug effects)
• Zinc (pharmacology)