Mutagenicity and tumor initiating activity of methylated benzo[k] fluoranthenes.

Abstract

The mutagenic activities toward Salmonella typhimurium TA100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF),2-methylBkF,8-methylBkF,9-methyl-BkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxy-BkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.

• Authors: S Amin, N Hussain, G Balanikas, K Huie, S S Hecht
• Journal: Cancer letters (Cancer Lett) Vol. 26 Issue 3 Pg. 343-7 (Apr 1985) ISSN: 0304-3835 [Print] Ireland
• PMID: 3995506 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Fluorenes
• Mutagens
• benzo(k)fluoranthene

Topics

• Animals
• Carcinogens
• Female
• Fluorenes (metabolism, toxicity)
• Mice
• Mutagens
• Skin Neoplasms (chemically induced)
• Structure-Activity Relationship