HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Induction of colorectal adenocarcinoma in rats by amylopectin sulfate.

Abstract
The carcinogenicity of orally administered amylopectin sulfate was studied in F344 rats. Amylopectin sulfate induced adenomas and adenocarcinomas in the rat colorectum. The incidences of tumor induction in groups that were given a 5% diet of amylopectin sulfate for 3, 6 and 9 months were 2 out of 20 rats (10%), 9 out of 20 rats (45%) and 12 out of 20 rats (60%), respectively. Squamous metaplasia of the colorectum persisted in all rats and progressed irreversibly. Amylopectin sulfate was deposited in the colorectal lamina propria, submucosa and regional lymph nodes. Amylopectin sulfate induced a lesion similar to that produced by degraded carrageenan in the rat colorectum.
AuthorsT Ishioka, N Kuwabara, Y Fukuda
JournalCancer letters (Cancer Lett) Vol. 26 Issue 3 Pg. 277-82 (Apr 1985) ISSN: 0304-3835 [Print] Ireland
PMID3995501 (Publication Type: Journal Article)
Chemical References
  • Amylopectin
  • amylopectin sulfate
Topics
  • Adenocarcinoma (chemically induced)
  • Amylopectin (toxicity)
  • Animals
  • Colon (pathology)
  • Colonic Neoplasms (chemically induced)
  • Male
  • Metaplasia
  • Molecular Weight
  • Rats
  • Rats, Inbred F344
  • Rectal Neoplasms (chemically induced)
  • Rectum (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: