Pharmacokinetics of prednisolone sodium succinate and its metabolites in normovolemic and hypovolemic dogs.

Abstract

Tritium-labeled prednisolone sodium succinate was administered IV to 4 healthy, awake, nonsplenectomized dogs. The concentration of prednisolone and its metabolites in the plasma were measured for 10 hours. Forty-one percent of the blood volume of these dogs was removed, and plasma prednisolone was measured again. The data before and after hemorrhage were fitted to a 2-compartment open model. From plasma profiles, a rapid distributional phase, followed by a slower phase, was observed in control and shock groups. Volume of the central compartment of prednisolone before and after hemorrhage was 165 ml/kg of body weight and 110 ml/kg, respectively; and the difference was significant (P less than 0.05). The rate of total body clearance of prednisolone before and after hemorrhage was 3.96 ml/min/kg and 2.53 ml/min/kg, respectively; the difference was significant. The mean plasma half-lives for prednisolone sodium succinate and its metabolites, before and after hemorrhage, were 166 and 197 minutes, respectively; the difference was not significant. The mean half-life data indicated that prednisolone sodium succinate may be repeated in a patient 2.5 to 3 hours after onset of treatment if signs of hypovolemic shock reappear.

• Authors: G H Hankes, L R Lazenby, W R Ravis, A A Belmonte
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 46 Issue 2 Pg. 476-8 (Feb 1985) ISSN: 0002-9645 [Print] United States
• PMID: 3994116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Prednisolone
• prednisolone hemisuccinate

Topics

• Animals
• Dog Diseases (metabolism)
• Dogs (metabolism)
• Female
• Injections, Intravenous (veterinary)
• Male
• Prednisolone (administration & dosage, analogs & derivatives, blood, metabolism)
• Shock (metabolism, veterinary)