Absorption of pentacaine from ulcerous rat stomach.

Abstract	Pentacaine is a local anaesthetic which exhibited positive effects on healing of model ulcers in the rat stomach. The in situ disappearance of pentacaine from the ulcerous and intact rat stomach was studied. Gastric ulcers were produced by oral administration of phenylbutazone (200 mg . kg-1) 3.5 h before absorption experiment. Pentacaine exhibited a biexponential decrease from the lumen of the stomach, the rate of which was essentially the same in both groups. The total amount of pentacaine absorbed was small because of extremely low absorption rate.
Authors	O Tomcíková, A Babulová, M Durisová, T Trnovec, L Benes
Journal	Die Pharmazie (Pharmazie) Vol. 40 Issue 1 Pg. 48-9 (Jan 1985) ISSN: 0031-7144 [Print] Germany
PMID	3991786 (Publication Type: Journal Article)
Chemical References	Anesthetics, Local Carbamates pentacaine
Topics	Absorption Anesthetics, Local (metabolism) Animals Carbamates (metabolism) Female Rats Rats, Inbred Strains Stomach Ulcer (metabolism) Time Factors

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