| Abstract | The role of cellular immunity in collagen arthritis was investigated with congenitally athymic nude rats (rnu/rnu) and their heterozygous littermates (rnu/+). Immunization with type II collagen induced polyarthritis and definite immunity to type II collagen in rnu/+ rats, whereas rnu/rnu rats did not develop arthritis or immunity to collagen. An additional study demonstrated that collagen arthritis could be passively transferred with a serum concentrate from arthritic Sprague-Dawley rats to naive rnu/rnu rats as well as to rnu/+ rats. Histopathologically, the passively transferred arthritis in rnu/rnu rats resembled that in rnu/+ rats. Despite no difference in clearance of anti-type II collagen antibody after transfer between them, the passively transferred arthritis in rnu/rnu rats was significantly enhanced and prolonged in comparison with that in rnu/+ rats. These results indicate that arthritis may be inducible by humoral immunity in the absence of functional T cells and also suggest that anti-type II collagen-antibody is not the sole regulatory factor and that the suppressor cell system might regulate the clinical course of the disease. |
| Authors | K Takagishi, N Kaibara, T Hotokebuchi, C Arita, M Morinaga, K Arai |
| Journal | Journal of immunology (Baltimore, Md. : 1950)
(J Immunol)
Vol. 134
Issue 6
Pg. 3864-7
(Jun 1985)
ISSN: 0022-1767 UNITED STATES |
| PMID | 3989301
(Publication Type: Journal Article)
|
| Chemical References |
- Autoantibodies
- Immune Sera
- Collagen
|
| Topics |
- Animals
- Arthritis
(etiology)
- Arthritis, Experimental
(etiology, genetics, immunology)
- Autoantibodies
(biosynthesis)
- Collagen
(immunology)
- Female
- Immune Sera
(administration & dosage)
- Immunity, Cellular
- Rats
- Rats, Inbred Strains
- Rats, Mutant Strains
(immunology)
- Thymus Gland
(physiopathology)
- Time Factors
|
