Iron-EHPG as an hepatobiliary MR contrast agent: initial imaging and biodistribution studies.

Abstract

The paramagnetic metal complex iron(III) ethylenebis-(2-hydroxyphenylglycine) [Fe(EHPG)-] is an effective hepatobiliary contrast agent for liver enhancement in magnetic resonance (MR) imaging. The intravenous administration of 0.2 mmol/kg of Fe(EHPG)- to rats yields a 200% increase in the signal intensity of the liver when using a T1-weighted inversion recovery pulse sequence on a 1.4 T imaging system. Biodistribution studies in rats and a rabbit, along with imaging studies in a dog at 0.6 T, confirm that the complex has significant hepatocellular uptake and appears to be excreted unaltered into the bile. Control experiments with a different iron complex, iron(III) diethylenetriaminepentaacetic acid, reveal little hepatic affinity and poor enhancement capability due to its extracellular distribution. This initial evaluation of Fe(EHPG)- demonstrates that paramagnetic metal complexes with hepatobiliary specificity are well suited for enhancement of normal liver parenchyma and may increase the sensitivity of MR in the detection of liver disease.

• Authors: R B Lauffer, W L Greif, D D Stark, A C Vincent, S Saini, V J Wedeen, T J Brady
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 1985 May-Jun Vol. 9 Issue 3 Pg. 431-8 ISSN: 0363-8715 [Print] United States
• PMID: 3989032 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Contrast Media
• Ethylenediamines
• Ferric Compounds
• Iron Chelating Agents
• ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid)
• Pentetic Acid

Topics

• Animals
• Biliary Tract (anatomy & histology)
• Contrast Media
• Dogs
• Ethylenediamines
• Female
• Ferric Compounds
• Iron Chelating Agents
• Liver (anatomy & histology)
• Magnetic Resonance Spectroscopy
• Male
• Pentetic Acid
• Rabbits
• Rats
• Rats, Inbred Strains
• Tissue Distribution