Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis.

Abstract

The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5-5.0 micrograms/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 +/- 100 to 2650 +/- 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 +/- 1.7 to 13.7 +/- 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure.

• Authors: G J Gross, D C Warltier, H F Hardman, S Shibata
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 110 Issue 2 Pg. 271-6 (Apr 02 1985) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3987818 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cardiotonic Agents
• Intercellular Signaling Peptides and Proteins
• Peptides
• anthopleurin-A

Topics

• Animals
• Blood Pressure (drug effects)
• Cardiotonic Agents
• Coronary Circulation (drug effects)
• Coronary Disease (physiopathology)
• Dogs
• Female
• Heart Rate (drug effects)
• Intercellular Signaling Peptides and Proteins
• Male
• Myocardial Contraction (drug effects)
• Peptides (pharmacology)