Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats.

Abstract

The effects of modifiers of the microsomal mixed-function oxidase system on acrylamide-induced hind-limb paralysis were investigated in rats. Pretreatment of rats with phenobarbital, trans-stilbene oxide or dichloro diphenyl trichloroethane (DDT) resulted in an earlier onset and subsequent development of acrylamide-induced hind-limb paralysis than that observed in animals treated only with acrylamide. Cobalt chloride pretreatment of rats caused a significant delay in the onset and development of hind-limb paralysis. Our results suggest that an intermediate formed by the cytochrome P-450 system may be responsible for acrylamide neurotoxicity.

• Authors: S P Srivastava, P K Seth, M Das, H Mukhtar
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 34 Issue 7 Pg. 1099-102 (Apr 01 1985) ISSN: 0006-2952 [Print] England
• PMID: 3985992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acrylamides
• Acrylamide
• Cobalt
• Cytochrome P-450 Enzyme System
• DDT
• Mixed Function Oxygenases
• cobaltous chloride
• Phenobarbital

Topics

• Acrylamide
• Acrylamides (metabolism, toxicity)
• Animals
• Cobalt (pharmacology)
• Cytochrome P-450 Enzyme System (metabolism)
• DDT (pharmacology)
• Enzyme Induction
• Male
• Mixed Function Oxygenases (metabolism)
• Nervous System (drug effects)
• Paralysis (chemically induced)
• Phenobarbital (pharmacology)
• Rats
• Rats, Inbred Strains