Abstract |
Changes in haemodynamic, inotropic state, and myocardial oxygen consumption were investigated in a total of eight patients with coronary artery disease after intravenous injection of 0.07 mg/kg amezinium methyl sulfate ( LU 1631, Supratonin). It was demonstrated, that the principal effects of amezinium are consistent with those of a sympathomimetic agent which stimulates vascular alpha- and beta 1-adrenoreceptors. Amezinium (0.07 mg/kg) increased cardiac index, mean arterial pressure and total systemic resistance and dp/dtmax, while there were only minor changes in stroke index, mean pulmonary pressure and total pulmonary vascular resistance. In accordance with the changes in haemodynamics there was a 21.5% increase in myocardial oxygen consumption. But there were no signs of imbalance between oxygen supply and oxygen demand.
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Authors | D Schaps, W Seitz, R Hetzer, A Tholen, D Goroll |
Journal | Der Anaesthesist
(Anaesthesist)
Vol. 34
Issue 2
Pg. 79-84
(Feb 1985)
ISSN: 0003-2417 [Print] Germany |
Vernacular Title | Kardiozirkulatorische Effekte des neuen Sympathomimetikums Ameziniummetilsulfat. Ergebnisse humanpharmakologischer Studien. |
PMID | 3985303
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Pyridazines
- Sympathomimetics
- amezinium
|
Topics |
- Adult
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Coronary Circulation
(drug effects)
- Coronary Disease
(drug therapy, physiopathology)
- Female
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Myocardium
(metabolism)
- Oxygen Consumption
(drug effects)
- Pyridazines
(pharmacology)
- Regional Blood Flow
(drug effects)
- Sympathomimetics
(pharmacology)
- Time Factors
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