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[Cardiocirculatory effects of a new sympathomimetic, amezinium methyl sulfate. Results of human pharmacological studies].

Abstract
Changes in haemodynamic, inotropic state, and myocardial oxygen consumption were investigated in a total of eight patients with coronary artery disease after intravenous injection of 0.07 mg/kg amezinium methyl sulfate (LU 1631, Supratonin). It was demonstrated, that the principal effects of amezinium are consistent with those of a sympathomimetic agent which stimulates vascular alpha- and beta 1-adrenoreceptors. Amezinium (0.07 mg/kg) increased cardiac index, mean arterial pressure and total systemic resistance and dp/dtmax, while there were only minor changes in stroke index, mean pulmonary pressure and total pulmonary vascular resistance. In accordance with the changes in haemodynamics there was a 21.5% increase in myocardial oxygen consumption. But there were no signs of imbalance between oxygen supply and oxygen demand.
AuthorsD Schaps, W Seitz, R Hetzer, A Tholen, D Goroll
JournalDer Anaesthesist (Anaesthesist) Vol. 34 Issue 2 Pg. 79-84 (Feb 1985) ISSN: 0003-2417 [Print] Germany
Vernacular TitleKardiozirkulatorische Effekte des neuen Sympathomimetikums Ameziniummetilsulfat. Ergebnisse humanpharmakologischer Studien.
PMID3985303 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Pyridazines
  • Sympathomimetics
  • amezinium
Topics
  • Adult
  • Blood Pressure (drug effects)
  • Cardiac Output (drug effects)
  • Coronary Circulation (drug effects)
  • Coronary Disease (drug therapy, physiopathology)
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Myocardium (metabolism)
  • Oxygen Consumption (drug effects)
  • Pyridazines (pharmacology)
  • Regional Blood Flow (drug effects)
  • Sympathomimetics (pharmacology)
  • Time Factors

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