[Dynamics of the basal gastrin concentration of duodenal ulcer patients during the development of remission of the disease].

Abstract

The authors describe the results of studying basal gastrin secretion in patients with peptic ulcer of the duodenum at different phases of disease treated in 3 stages. It was revealed that basal secretion of gastrin experienced substantial changes in the course of transition from the phase of exacerbation to the phase of disease remission. It was noted that the onset of the clinico-endoscopic remission of peptic ulcer did not correlate in all the cases with normalization of basal gastrin level. Patients who did not show normalization of basal gastrin level during treatment were more prone to the development of repeated exacerbations. Based on the data obtained the authors determined the prognostic importance of radioimmunoassay of gastrin basal concentration over time. The increment of gastrin concentration by more than 35 pg/ml of the level seen during peptic ulcer exacerbation is a prognostically unfavourable sign, for the probability of relapses rises up to 79% during a year.

• Authors: V G Smagin, I O Ivanikov, V A Vinogradov, S A Chorbinskaia
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 57 Issue 1 Pg. 78-80 ( 1985) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Dinamika bazal'noĭ kontsentratsii gastrina u bol'nykh duodenal'noĭ iazvoĭ v protsesse stanovleniia remissii zabolevaniia.
• PMID: 3983850 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Gastrins

Topics

• Adult
• Aged
• Chronic Disease
• Duodenal Ulcer (blood, therapy)
• Duodenoscopy
• Gastrins (blood)
• Humans
• Male
• Middle Aged
• Prognosis
• Radioimmunoassay
• Recurrence
• Time Factors