Rapid clearance of iodine-131 MIBG from the heart and liver of patients with adrenergic dysfunction and pheochromocytoma.

Abstract

Iodine-131 MIBG, a radiolabeled adrenergic neuron-blocking agent, decreased rapidly from the heart and liver of patients with adrenergic dysfunction (n = 3) and pheochromocytoma (n = 2) when compared with eight controls. The 4-hr activity expressed as percentages (mean +/- s.d.) of the 20-min counts were as follows: 80 +/- 3.0% in the controls compared with 60 +/- 7.6% in the patients over the heart (p less than 0.01) and 79 +/- 3.2% in the controls compared with 51 +/- 17% in the patients over the liver (p less than 0.02). However, there was no significant difference in the rate of [131I]MIBG decrease in these organs between controls and patients in the intervals subsequent to 4 hr (p greater than 0.05). These findings suggest that adrenergic neuronal uptake of [131I]MIBG in these organs is smaller in the patients than in the controls. Measurements of time-activity relationships of radioiodinated MIBG may be useful for assessment of adrenergic function of these organs and thus of generalized disorders of adrenergic innervation.

• Authors: M Nakajo, K Shimabukuro, N Miyaji, J Shimada, K Shirono, H Sakata, H Yoshimura, R Yonekura, S Shinohara
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 26 Issue 4 Pg. 357-65 (Apr 1985) ISSN: 0161-5505 [Print] United States
• PMID: 3981255 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Iodine Radioisotopes
• Iodobenzenes
• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine
• Adrenal Gland Neoplasms (diagnostic imaging, metabolism)
• Adult
• Aged
• Autonomic Nervous System Diseases (diagnostic imaging, metabolism)
• Female
• Heart (diagnostic imaging)
• Humans
• Iodine Radioisotopes (metabolism)
• Iodobenzenes (metabolism)
• Liver (diagnostic imaging, metabolism)
• Lung (diagnostic imaging)
• Male
• Middle Aged
• Myocardium (metabolism)
• Pheochromocytoma (diagnostic imaging, metabolism)
• Radionuclide Imaging
• Shy-Drager Syndrome (diagnostic imaging, metabolism)
• Time Factors