Inhibition of canine gastric secretion by the prostanoid Ro 22-6923.

Abstract

The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated acid secretion at an oral dose of 0.5 mg/kg. The effect lasted for 4 hr and was of greater intensity than that observed with 5 mg/kg cimetidine. The ED50 for Ro 22-6923 in this model was 0.25 mg/kg and 0.09 mg/kg for oral and intrapouch administration, respectively. Natural prostaglandin E2 was inactive up to 1 mg/kg orally, but had an ED50 of 0.08 mg/kg when administered directly into the pouch. The results indicate that Ro 22-6923 is a potent, long-acting antisecretory drug that may be useful in the therapy of peptic ulcer disease in man.

• Authors: T S Gaginella, R J Bertko, R K Müller, H Gallo-Torres, A C Sullivan
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 30 Issue 4 Pg. 340-5 (Apr 1985) ISSN: 0163-2116 [Print] United States
• PMID: 3979240 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Prostaglandins E, Synthetic
• Cimetidine
• Ro 22-6923

Topics

• Animals
• Anti-Ulcer Agents (pharmacology)
• Cimetidine (pharmacology)
• Dogs
• Dose-Response Relationship, Drug
• Female
• Gastrectomy
• Gastric Acid (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Male
• Prostaglandins E, Synthetic (pharmacology)
• Time Factors