Oncogene expression in rat hepatomas and during hepatocarcinogenesis.

Abstract

In this study we examined oncogene expression in several Morris hepatomas. We found elevated transcripts for Ha-ras, Ki-ras, and the myc oncogenes, while the src oncogene was not increased. Northern analysis revealed transcript sizes of 1.4 kb for Ha-ras and 2.5 kb for myc. Analysis of primary tumors induced by the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MDAB) showed increasing oncogene transcript production with increasing length of diet. The results show enhanced ras and myc expression in rat hepatocellular carcinomas and during hepatocarcinogenesis.

• Authors: G J Cote, B A Lastra, J R Cook, D P Huang, J F Chiu
• Journal: Cancer letters (Cancer Lett) Vol. 26 Issue 2 Pg. 121-7 (Mar 1985) ISSN: 0304-3835 [Print] Ireland
• PMID: 3978602 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA, Neoplasm
• Methyldimethylaminoazobenzene

Topics

• Animals
• Liver Neoplasms, Experimental (chemically induced, genetics)
• Male
• Methyldimethylaminoazobenzene
• Oncogenes
• RNA, Neoplasm (analysis)
• Rats
• Rats, Inbred F344