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Acanthosis nigricans-like hyperpigmentation secondary to triazinate therapy.

Abstract
Cutaneous hyperpigmentation resembling acanthosis nigricans developed in two patients with malignant brain tumors following chemotherapy with triazinate (Baker's Antifol), a folic acid antagonist. In both cases, the eruption resolved after the cessation of drug administration and reappeared after the reinstitution of triazinate therapy. A skin biopsy specimen from one patient showed microscopic changes consistent with those found in acanthosis nigricans. The other patient had a decreased serum folate level that returned to normal as the hyperpigmentation resolved. Folate may have a role in triazinate-induced acanthosislike hyperpigmentation.
AuthorsA H Greenspan, J L Shupack, S H Foo, A C Wise
JournalArchives of dermatology (Arch Dermatol) Vol. 121 Issue 2 Pg. 232-5 (Feb 1985) ISSN: 0003-987X [Print] United States
PMID3977338 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Triazines
  • triazinate
Topics
  • Acanthosis Nigricans (diagnosis)
  • Adult
  • Antineoplastic Agents (adverse effects)
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Pigmentation Disorders (chemically induced, diagnosis, pathology)
  • Skin (pathology)
  • Triazines (adverse effects)

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