Myoglobin, creatine kinase and creatine kinase subunit-beta in serum from patients and relatives with hypokaliaemic familial periodic paralysis.

Abstract

Increased levels of serum myoglobin (S-myoglobin) were found in 6 investigated patients with hypokaliaemic familial periodic paralysis (hypoKPP) in their habitual condition. Furthermore, in 3 of the 6, increased levels of serum creatine kinase (S-CK) were found. These findings support the hypothesis that hypoKPP is a permanent myopathy, which is aggravated during attacks. It was found that 1 definite carrier had elevated S-myoglobin and among healthy relatives 6/11 had elevated S-myoglobin and 3/11 elevated S-CK. The use of S-myoglobin and S-CK for carrier detection is discussed.

• Authors: P Wiggers, K Nørregaard-Hansen
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 71 Issue 1 Pg. 69-72 (Jan 1985) ISSN: 0001-6314 [Print] Denmark
• PMID: 3976355 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoenzymes
• Myoglobin
• Creatine Kinase

Topics

• Adolescent
• Adult
• Aged
• Child
• Creatine Kinase (blood)
• Female
• Genetic Carrier Screening
• Humans
• Hypokalemia (enzymology, genetics)
• Isoenzymes
• Male
• Middle Aged
• Myoglobin (blood)
• Paralyses, Familial Periodic (enzymology, genetics)