Enhancement of phenol-induced tremor caused by central monoamine depletion.

Abstract

The effects of monoamine depletors and monoamine denervators on phenol-induced tremor were studied in mice. The tremor induced by phenol was enhanced by pretreatment with reserpine or tetrabenazine, but not with syrosingopine. However, alpha-methyl-p-tyrosine, p-chlorophenylalanine or 6-hydroxydopamine did not affect the tremor. These results suggest that the depletion of central monoamines as a whole contribute to the enhancement of the tremor induced by phenol.

• Authors: T Suzuki, K Kisara
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 22 Issue 1 Pg. 153-5 (Jan 1985) ISSN: 0091-3057 [Print] United States
• PMID: 3975240 (Publication Type: Journal Article)

Chemical References

• Monoamine Oxidase Inhibitors
• Phenols
• Phenol

Topics

• Animals
• Dose-Response Relationship, Drug
• Drug Synergism
• Male
• Mice
• Monoamine Oxidase Inhibitors (pharmacology)
• Phenol
• Phenols (pharmacology)
• Time Factors
• Tremor (chemically induced)