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Selective induction of nasal cavity tumors in rats by diallylnitrosamine.

Abstract
Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.
AuthorsP M Pour, C J Grandjean, S Knepper
JournalJournal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 109 Issue 1 Pg. 5-8 ( 1985) ISSN: 0171-5216 [Print] Germany
PMID3972886 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Nitrosamines
  • diallylnitrosamine
Topics
  • Adenocarcinoma (chemically induced)
  • Administration, Oral
  • Animals
  • Carcinoma (chemically induced)
  • Carcinoma, Squamous Cell (chemically induced)
  • Female
  • Male
  • Nasal Cavity (drug effects, pathology)
  • Nitrosamines (toxicity)
  • Nose Neoplasms (chemically induced, pathology)
  • Papilloma (chemically induced)
  • Rats
  • Rats, Inbred Strains
  • Time Factors

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