Abstract |
Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.
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Authors | P M Pour, C J Grandjean, S Knepper |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 109
Issue 1
Pg. 5-8
( 1985)
ISSN: 0171-5216 [Print] Germany |
PMID | 3972886
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Nitrosamines
- diallylnitrosamine
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Topics |
- Adenocarcinoma
(chemically induced)
- Administration, Oral
- Animals
- Carcinoma
(chemically induced)
- Carcinoma, Squamous Cell
(chemically induced)
- Female
- Male
- Nasal Cavity
(drug effects, pathology)
- Nitrosamines
(toxicity)
- Nose Neoplasms
(chemically induced, pathology)
- Papilloma
(chemically induced)
- Rats
- Rats, Inbred Strains
- Time Factors
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